Ten creatives will receive £1,000 and development opportunities via Manchester International Festival's MIF Sounds initiative.
MIF Sounds launched at the height of the pandemic, helping musicians to continue working and work outside their comfort zone during an uncertain time.
This year's applicants can apply for anything from recording music, presenting a gig, releasing a record or starting a label imprint.
MIF Head of Music Jane Besse said the company is committed to helping rebuild the sector post-Covid.
One in three music sector jobs were lost in the sector as employment fell from a high of 197,000 in 2019 to 128,000 people in 2020, according to UK Music.
"We encourage everyone involved in the local music scene to apply - artists, technicians, promoters, venues, labels, managers and beyond," Besse said.