The Museum of Making in Derby will be closed after it suffered "significant" damage from flooding caused by Storm Babet.
Derby Museums said the building was exposed to "substantial" quantities of water, with the museum closed while insurers are called in to assess the damage.
The museum's collections are undamaged, as the majority are housed on the upper floors of the building.
Tony Butler, executive director of Derby Museums, said: "We were all devastated to wake up to the floods on Saturday morning.
"Our team worked hard to secure the Museum of Making and protect our collections, which I am pleased to say are safe and undamaged.
"We are sorry to be closed to the public in the coming days. I’d like to thank our fantastic supporters, both individuals and the local business community; as always, we have been overwhelmed by your love and appreciation for Derby Museums."