Nine events in April and May will be used as test pilots for the Government's plan to return to live events this summer.
The Events Research Programme will provide key data and insights into reopening events safely, exploring different approaches to social distancing, ventilation and test-to-enter schemes. Covid status certification will also be trialled.
At some events, attendees will not be socially distanced but will be required to wear fask masks and take a Covid test before and after the events.
All the cultural sector events will take place in Liverpool, with Liverpool City Council closely involved in preparations.
Among the events are an April 16 show for 300 people at Hot Water Comedy Club, Luna Outdoor Cinema for 1000 people and Circus Nightclub, an indoor club night with capacity for 3000.
Liverpool's Director of Public Health Matthew Ashton said the city hopes it can provide evidence to support the cultural sector's reopening.
"Our experience as the pilot city for mass symptom-free testing means we have the knowledge and infrastructure in place to deliver complicated projects safely.
"This is a continuation of the city’s long-standing tradition of carrying out pioneering public health work that not only has an impact here, but also across the rest of the country and the wider world.”
Sheffield's Crucible Theatre will once again host the World Snooker Championships, proving the effectiveness of Covid control measures in a theatre setting.